All of the active B12 group reporting showed reduction in severity of symptoms ranging from 31% to 70%, while nutrition and diet the placebo controls reported nutrition either no change or a worsening of symptoms. Wilcoxon-Rank of .002 for the end-points of sneezing, nasal congestion and runny nose; and p = .005 diet for IgE reductions. In 1992, the above mentioned data from 1988 on were presented by Dr. O''Connor to the FDA. The FDA panel acknowledged the safety of the treatment. The panel seemed to be in agreement that the statistics indicated a significant reduction in IgE and that a quantitative drop in symptoms was demonstrated. In 1992, Belen Anibarro, MD, studied five children with asthma with metabisulfite intolerance confirmed by oral challenge testing. The test was repeated after premedication nutrition with 1.5 mg of oral cyanocobalamin. diet In four of the five patients treated, bronchospasm nutrition did not develop in the second metabisulfite challenge.6

Studies diet indicate that ingested oral nutrition cyanocobalamin tablets are ineffective in the treatment of allergic disease, perhaps because diet once ingested, they are directly metabolized in the liver. When B12 is delivered via injection nutrition or diet lozenge it passes throughout the bloodstream before arriving at the liver. It is during this first pass in its native form that it is believed to exert its therapeutic effect. CLINICAL nutrition RESEARCH: "The World Health Organization (WHO) recognizes allergic rhinitis (hay fever), sinusitis, diet asthma,...conjunctivitis, urticaria, eczema, dermatitis (contact and atopic)...allergic and migraine headache...as diseases nutrition in which IgE-mediated allergy may be involved."1 In 1988, asthma and allergic rhinitis subjects were treated with B12. Total IgE, specific IgE and pulmonary lung functions were taken at days 45, 150 and 180 from baseline. Eight of the 9 subjects had reduced IgE. 2 In 1989 open label studies at two sites in Riverside County, CA in 1989. Sixteen of the 17 subjects had lowered IgE levels from Day 0 to Day 30.3

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